Once a gene list is supplied and enrichment results have been returned, a subset of genes corresponding to those that contain a particular anno­tation may be isolated and re-run through the tool to be analyzed as a separate, smaller gene list. This allows users to select a particularly inter­esting group of functionally related genes and isolate them to see if they are also enriched for other functional terms. This also allows the user to prune large gene lists into more focused lists of functionally similar genes and removing some of the inherent noise associated with high-throughput experimental techniques and their resulting gene lists. This feature of the tool may be accessed by expanding the enrichment results of a particular annotation and selecting to re-run the analysis using only that subset of proteins. From this step, users may select which database types to query for enrichment (e. g. pathway, ontology, protein family).

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